When choosing a collagen supplement consider these points. Denatured chemistry changes the structure of proteins so it loses come of its unique characteristics. An undenatured protein retains its specific characteristics and with collagen this is an important element with regard to the quality and efficacy of the material. Common forms of collage are types I-V. Type II is the main collagenous component of cartilage.
Research on rheumatoid and osteoarthritis patients has shown that undenatured type II collagen has benefits for joint health because it works with the immune system by a process called oral tolerance. This process helps the body to differentiate between foreign invaders like bacteria, and nutrients that are good for the body. It takes place in the small intestine when most absorption happens and where patches of lymphoid tissue surrounding the small intestine screen incoming compounds and alert the body to “foreigners”. Taking type II at bedtime seems to suppress the action of cells and gives the collagen a better chance of being broken down and admitted as a beneficial compound.
Rheumatoid arthritis is considered an auto-immune response when the body’s own immune system attacks joint tissue. Studies have show that patients taking type II undenatured collagen showed a better response and significant improvement. Clinical trials have also showed benefit on osteoarthritis patients.
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