Constance Harrell of Emory Univ. tested adolescent rats to see the effect of a high fructose diet on their responses to stressors. She determined that this diet was linked to their depressive-like behavior. A genetic pathway in the brain that plays a key role in regulating the way the brain responds to stress was also altered. These findings indicate that consuming a diet high in fructose throughout adolescence may exacerbate depressive behaviors and affect the way the body and brain respond to stress. If you are depressed now, what was your diet like when you were younger?